SciDev.Net story prompts antibiotic ban in Indian agriculture, protecting ‘drug of last resort’

In brief:每年，印度有58,000多名婴儿死于新生儿败血症。抗生素由于过度使用（包括农业）而变得越来越有效。beplay下载官网西西软件SciDev.Netpublished a story about the importance of maintaining the antibiotic colistin as a drug of last resort against neonatal sepsis, stimulating the debate that led to the ban of colistin in agriculture.

Why it matters:高水平的抗生素过度使用使许多药物具有抗药性。但是，包括大肠菌素在内的世界卫生组织限制的少数药物构成了发展新生儿败血症的婴儿的最后一条防御线。

大局：根据世界卫生组织的说法，抗生素耐药性是对当今全球健康，粮食安全和发展的最大威胁之一。随着抗生素的有效性降低，感染变得越来越困难。

By the numbers:Neonatal sepsis, a systemic infection in the first 28 days of life, is the third most common cause of death among infants less than four weeks old, accounting for 225,000 deaths globally every year.[1]

Background

In hospitals across India, babies are dying for lack of working antibiotics. Despite cleanliness and vigilance, drug-resistant microbes infect infants causing neonatal sepsis, a condition that kills over 58,000 babies every year.[2]

One relatively obsolete antibiotic, colistin, has been used successfully to prevent neonatal sepsis. In 2019, Dr Dinesh Raj, a paediatrician working at the Holy Family Hospital in New Delhi, explained: “Because of the resurgence of drug-resistant pathogens, it is being used as a drug of last resort.”

However, Dr Sumbul Warsi, medical director of the Holy Family Hospital believed that the “irrational and inappropriate” use of antibiotics, including misuse in agriculture, was contributing to “antibiotic resistance and rising instances of neonatal ”.

Given the liberal use of colistin in poultry farming, it was unclear how long the antibiotic could remain effective.

Already in 2017, the World Health Organization recommended that “farmers and the food industry stop using antibiotics routinely … in healthy animals”, listing colistin as one of the critically important antimicrobials for human medicine.

India’s Drugs Technical Advisory Board, part of the Ministry of Health and Family Welfare, also recommended that colistin and other antimicrobials not be used in agriculture but, as of early 2019, no formal ban had been adopted.

What action didSciDev.Nettake?

SciDev.NetRegional Coordinator for Asia Pacific, Joel Adriano, had been following the growing crisis in antibiotic misuse and resistance in India. In mid-2019, he heard about the specific use of colistin to reduce infant mortality.

At the time, no other news outlets had covered colistin in detail. Adriano commissioned a comprehensive story fromSciDev.Netjournalist Ranjit Devraj; the story was escalated toSciDev.Net’s global desk.

康泰克Devraj伸出ts in the Indian Agricultural Research Institute (ICAR) and the Holy Family Hospital in New Delhi. He spoke to agricultural scientists and top medical experts and paediatricians to understand the potential benefit of colistin and the dangers in continuing to use it in agriculture.

2019年7月5日，SciDev.Netpublished an in-depth news story under the title,The awful toll of superbugs in India’s hospitals. The article focused on interviews with paediatricians who had come face to face with colistin use in hospitals, rather than focusing on the research community, which other articles on antibiotic misuse had done up to this point.

SciDev.Netwas the first and only outlet to cover the story with this angle. Major Indian news portals picked up and publishedSciDev.Net’s story; other outlets cited it.

What was the impact ofSciDev.Net’s action?

On 22 July 2019, a little over two weeks after theSciDev.Netarticle was published, the Indian Ministry of Health and Family Welfare banned the use of colistin in agriculture. Specifically, it prohibited the manufacture, sale and distribution of colistin and its formulations for food-producing animals, poultry, aqua farming and animal feed supplements.

Devraj later learned from his contacts in ICAR that his article had played an important role in stimulating the debate that led to the ban, helping to raise awareness among key decision makers and policy makers about the importance of maintaining colistin as an antibiotic of last resort.

Sushil Kumar, IAS, Secretary, SC National Commission, former Secretary of ICAR and Additional Secretary, Ministry of Agriculture, said:

“TheSciDev.Netstory by Ranjit Devraj positively and proactively enhanced the debate on the use of the colistin for agricultural purposes. He held discussions with top agriculture scientists of Indian Council of Agriculture Research and senior officials handling policy planning matters in the Ministry. As a result of his passionate espousal of sustainable agriculture and related nationwide debate, colistin was banned for use in agriculture. This marks another success in highlighting important issues of public policy where Mr Devraj has actively contributed.”

• Neonatal sepsis accounts for 225,000 deaths globally every year.[3]Globally, of the three million annual neonatal sepsis cases (2,202/ 100,000 live births), India has the highest incidence of clinical sepsis (17,000/ 100,000 live births).[4]By safeguarding colistin as a drug of last resort, the lives of potentially hundreds of thousands of infants in India can be protected.

Relevant SDG: