25/07/19

谁推荐Dolutegravir作为首选HIV治疗

HIV Virus Main
HIV breaks down and attacks the body's T cells so that it is unable to defend itself against different infections. WHO is “strongly recommending” dolutegravir (DTG) to treat patients. Copyright: Image byDarwin LaganzonfromPixabay(This image has been cropped.)

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  • WHO recommends dolutegravir (DTG) for all living with HIV, including pregnant women
  • Drug had previously been named as a possible cause of neural tube defects
  • New evidence shows risks are ‘significantly lower’ than thought: WHO

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[墨西哥城]现在被担心引起严重先天缺陷的药物现在是首次选择的治疗方法HIVafter the World Health Organization (WHO) said the risks were “significantly lower” than previously thought.

The WHO said it had changed its guidelines to “strongly recommend” dolutegravir (DTG) as the preferred first- and second-line treatment for all populations living with thedisease, including pregnant women and those of childbearing potential.

Last year, many countries advised pregnant women or those who might become pregnant to take efavirenz (EFV) instead, after a study in Botswana found a possible link between DTG and neural tube defects in newborn babies. These are defects of the brain, spine or spinal cord that develop in early pregnancy.

“To reverse the misperception about the level of risk will take another year. We lost two years in access to a drug that will save women's lives,”

Deborah Birx, US global AIDS coordinator

However, presentingnew researchfrom the ongoing Tsepamo study at the International AIDS Society (IAS)Conference on HIV Science, in Mexico, the WHO said the potential risk was “significantly lower” than previously estimated, with benefits for women probably outweighing the drawbacks.

事实证明,DTG更安全,副作用较少,并用作geneticbarrier todrugresistance to other antiretrovirals (ART) such as EFV, according to the WHO.

According to international organisation Unitaid, DTG-based regimes could enable low- and middle-income countries to expand ART therapy fast enough to reach联合国目标to end the HIV/AIDS epidemic by 2030, although challenges remain in terms ofprices for low-income countries.

Besides the new studies on the risk of neural tube defects, the newWHO guidelineswere based on mathematical models on the benefits and harms of DTG versus EFV, as well as the preferences of communities living with HIV, especially women, who globally represent half of the estimated 37.9 million affected by the disease.

Meg Doherty, from the WHO’s department of HIV, hepatitis and sexually transmitted infections, toldSciDev.Net: “Women don’t want to be told what they have to take; they want to be able to negotiate and discuss, having a conversation. And that doesn’t happen as often in very overcrowded, overburdened health centres or systems.”

Jaqueline Wambui, of the National Empowerment Network of People Living with HIV and AIDS in Kenya, said global and local health policies on HIV must take into account “what happens on the ground”.

Wambui believes the context in which these drugs are provided is key to understanding the prevalence of the disease.

例如,不到40%的女性生活with HIV have access to family planning services, according to the WHO, and folic acid supplementation, which helps prevent neural tube defects, is not always guaranteed.

Wambui说,要使女性能够做出更明智的决定,我们必须解决专业知识与社区之间的“沟通差距”。

“We have a lot of people stopping the treatment because they don’t understand they have to take it for a certain period of time, especially with HIV treatment, that it’s a lifetime treatment,” she said.

Wambui, who has HIV, experienced this first-hand. Two years after being diagnosed, she developedtuberculosis因为她停止接受治疗,她告诉SciDev.Net, adding: “[It was] probably because I wasn’t prepared to take medication the rest of my life. If I had had the proper information about the risks of leaving the medication, I probably wouldn’t have had tuberculosis.

“We have seen a lot of science but we need to take into account what the people affected think of its developments.”

In 2019, 82 low- and middle-income countries have said they have transitioned to DTG-based treatment for HIV, the WHO has reported, although some fear that perceptions around the risks of the drug could take more time to change.

Deborah Birx, US global AIDS coordinator, told the IAS conference on Monday: “To reverse the misperception about the level of risk will take another year. We lost two years in access to a drug that will save women's lives.”

Rebecca Zash, Harvard researcher and lead author of the DTG safety studies, told the conference a public health approach to ART that maintains gender equity requires pregnancy safety data. One of the lessons of the Tsepamo study, she said, is that we need “sustainable surveillance” in the high HIV-burden countries, where more than 90 per cent of ART pregnancy exposures occur.